Donor Work-Up

Short Term Complications
Mortality- 0.03-0.05%
Atelectasis- 15-30%
Nerve injury- 6%
UTI- 5%
Pneumothorax- 5%
Wound infection- 3%
Blood transfusion- 3%
Pneumonia- 1%
Splenectomy- 0.3%
Pulmonary embolism- 0.3%

Selection criteria
• Siblings/parents → best
• 18-65 y/o
• ABO compatibility
• HLA A, B, DR phenotype →priority in 1 or 2 haplotype match

Absolute Contraindication
• Proteinuria > 0.3g/24h Hematuria
• Impaired renal function
• BP>140/90
• DM, IGT in family with T2DM, Gestational DM
• Psychiatric illness
• Coagulopathy
• Systemic illness with potential to cause renal ds
• Drug abuse
• Severe cardiac/pulmonary disease
• Infectious disease
• Pregnancy
• ADPKD
<30y/o: 2 cyst in either kidney, 30-59 y/o: 2 cyst in each kidney
Over 60: 4 cyst in each kidney

Relative Contraindication
• BMI>30
• Related donor and recipient has T1DM
• Nephrolithiasis. Safe if
o Inactive for 10 yrs
o 1 stone passes only
o no radiological evidence of stone
• Malignancy
• HepB/C
o Hep B: OK if donor is eAg-ve and recipient has AB
o Hep C: OK if both have same genotype
• Alport. Safe if
o Male and no hematuria
o Female relatives may be carrier. Need to counsel that their son may have the disease
o Donor with no alport may cause anti GBM